The HFSP Journal publishes high quality, innovative research at the frontier of biology with an emphasis on interdisciplinary research at the interface between the life sciences and the more quantitative sciences.
The goal of the HFSP Journal is to further the mission of the Human Frontier Science Program. It should be stressed, however, that the HFSP Journal is independent from the Human Frontier Science Program Organization and that submission to the HFSP Journal is open to all and that it is not restricted to awardees of HFSP grants and fellowships.
A truly interdisciplinary reviewing process: 'the reviewers' comments were unusually insightful and useful - spanning from mistakes in equations and other typos, to interesting suggestions for discussion. As an author I can say that this is really a very encouraging start for a new journal', Prof. Dan S. Tawfik from the Weizmann Institute of Science's department of Biological Chemistry in Rehovot, Israel explains.
Qubits: Qubits fast-track free open access publication of short reports on arising matters.
Current Issue Table of Contents
EDITORIALS
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COMMENTARIES
This Commentary discusses a study which combines computational network identification with extensive experimentation and literature mining to discover and validate numerous regulatory interactions among ten genes involved in the cellular response to glucose starvation in yeast. Low levels of glucose (calorie restriction) have been known to extend the longevity of various eukaryotes. This study demonstrates that a key regulator of glucose repression, Snf1 and two of its newly discovered synergistic repressors significantly affect the chronological lifespan.
pp. 94-99
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This Commentary discusses a recent article showing auto-oscillatory movement/tension development in an in vitro motility assay composed of a single actin filament and randomly distributed myosin II molecules, suggesting that the auto-oscillatory properties are inherent to the contractile proteins.
pp. 100-104
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Evolvability is the property of a biological system to quickly adapt to new requirements. Robustness seems to be the opposite. This Commentary discusses a recently published model which shows that, depending on the mutation rate and the number of accessible phenotypes at any given genotype, evolvability and robustness can be reconciled.
pp. 105-108
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PERSPECTIVES
This Perspective discusses the development of biocrystallography from the pioneers' time to the coming era of global biology in relation with the development of technical advances for structure determination and molecular sample preparation.
pp. 109-121
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This Perspective discusses the theoretical models of the self-organization of the cytoskeleton in yeast.
pp. 122-130
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ARTICLES
This works provides experimental insight into the process of evolution and adaptation. A large fraction of yeast cells adapted to grow in a selective medium and this adaptation was stably inherited. The adaptation is shown to be due to a response of many individual cells to the change in environment and not due to selection of rare advantageous phenotypes.
pp. 131-141
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This article presents a three-dimensional computational model of amphibian neurulation.
pp. 142-152
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This article addresses the fundamental question of encoding in neuroscience. In particular, evidence is presented in support of an emerging model of neuronal encoding in the neocortex based on spatiotemporal patterns of spikes.
pp. 153-163
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 Vol. 3 Iss. 6 December 2009 |
 Vol. 4 Iss. 1 February 2010 |
 Vol. 4 Iss. 2 April 2010 |
 Vol. 4 Iss. 3 June 2010 |
Goals of the HFSP Journal
- to serve as a forum for communication between scientists from different disciplines who are focusing on problems in the life sciences
- to ensure a system of efficient peer review that does justice to all aspects of an interdisciplinary article (the usual time between submission and first decision is about a month)
- to place studies from different disciplines in a context accessible to scientists from different fields
- to ensure rapid online publication of original articles; the usual time between acceptance and online publication is one month
- to further the scientific mission of the Human Frontier Science Program
Scope of the HFSP Journal
Types of articles
- primary research articles
- commentaries on articles published in the HFSP Journal and other publications
- perspectives articles on important trends in interdisciplinary research